Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media

• Status: Completed
• Trial end date: 2006-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Chronic suppurative otitis media is one of the most common chronic infections in children worldwide. Symptoms include otorrhea, otalgia and hearing loss. In many countries, it is treated primarily with antibiotics; in other countries such as the Netherlands a surgical approach, such as a tonsillectomy, adenoidectomy, placement or removal of tympanostomy tubes or a tympanomastoidectomy is preferred. There is however, no agreement on the management of this disease.

The purpose of this study is to determine the effectiveness of treatment with sulfamethoxazole-trimethoprim for 6-12 weeks in children suffering from chronic otitis media and otorrhea.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UMC Utrecht
• Collaborator: Dutch Health Care Insurance Board
• Treatments: Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Criteria

Inclusion Criteria:

• age between 1 and 12 years

• otorrhea for more than 3 months

Exclusion Criteria:

• cholesteatoma

• known immune deficiency other than IgA or IgG2

• Down's syndrome

• craniofacial anomalies

• cystic fibrosis

• immotile cilia syndrome

• allergy to sulfamethoxazole-trimethoprim

• continuous use of sulfamethoxazole-trimethoprim for more than six weeks in the past six months