Effectiveness of Propranolol For Treating People With Post-Traumatic Stress Disorder

• Status: Terminated
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the effectiveness of propranolol in reducing symptoms of distress in people with post-traumatic stress disorder.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Weill Medical College of Cornell University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of PTSD or meets the five of the six diagnostic criteria for PTSD (event, hyperarousal, re-experiencing, duration, and distress/impaired functioning symptom criteria), but not the avoidance/numbing symptom criteria

Exclusion Criteria:

• Past or current asthma

• Diabetes or heart disease

• Currently pregnant or breastfeeding

• Concurrent use of daily benzodiazepine; daily use of antidepressant medication allowed if dose has been stable for the 3 months before study entry

• Exposure therapy or additional cognitive therapy during the course of the study (supportive psychotherapy is allowed if ongoing for at least 3 months before study entry)

• Substance abuse

• Current use of beta blockers, amiodarone, chlorpromazine, cimetidine, clonidine, or digoxin