Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block
Status:
Recruiting
Trial end date:
2022-01-15
Target enrollment:
Participant gender:
Summary
Purpose: The aim of this prospective, double-blind, randomized controlled trial is to compare
the effect of oral premedication of dexamethasone, ketorolac, meloxicam, ibuprofen or placebo
on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in
patients experiencing symptomatic irreversible pulpitis. Methods: The trial will include five
study groups, each consists of 50 patients who exhibits symptomatic irreversible pulpitis of
a mandibular first or second molar. The patients will receive identically appearing capsules
containing either dexamethasone 0.5 mg, ketorolac 10 mg, meloxicam 7.5 mg, ibuprofen 600 mg,
or placebo by mouth 60 minutes before the administration of an IANB. Endodontic access will
begin 15 minutes after completion of the IANB. The IANB success is defined as no or mild pain
(Heft Parker visual analog scale recordings) on pulpal access or instrumentation.