Effectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan Children

• Status: Unknown status
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

We will test the hypothesis that there is a difference in effectiveness of oral quinine in comparison to artemether Lumefantrine in the treatment of uncomplicated malaria in children.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Makerere University
• Collaborators: Ministry of Health, Uganda; Uganda Malaria Surveillance Project
• Treatments: Artemether; Artemether-lumefantrine combination; Artemether, Lumefantrine Drug Combination; Artemisinins; Lumefantrine; Quinine

Criteria

Inclusion Criteria:

1. Aged between 6 and 59 months of age seen at the assessment centre during the study period

2. With fever defined as axillary temperature ≥37.5 °C or history of fever in the past 24 h

3. With a microscopically confirmed monoinfection of Plasmodium falciparum

4. Able to tolerate oral therapy,

5. Whose parents/guardians have provided written informed consent.

Exclusion Criteria:

1. Children with a history of allergy to quinine, artemether-Lumefantrine or milk.

2. Evidence of severe malaria.

3. Residence at more than 20km from the health clinic.

4. Evidence of a significant concomitant febrile illness that would require hospitalization or chronic medical illness