Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
The intent of the proposed study is to assess the potential of oral insulin to mitigate
diabetic instability and reduce the frequency and severity of hypoglycemic episodes in
patients with type 1 diabetes. Restoring hepatic glycogen stores is critical for the
normalization of counter-regulation to hypoglycemia in these patients. Oral insulin can
provide a means to increase portal insulin levels, shift the ratio of insulin/glucagon in
favor of glycogenesis while sparing the patient the risk of hypoglycemia due to peripheral
hyperinsulinemia