Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic Strategy
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Quality of life of adult patients with sickle cell disease is deeply impaired by severe
adverse medical events that inadvertently occur throughout their time life. Indeed, patients
not presenting a life threatening condition often present to the emergency department with
sickle cell disease crisis related pain. Currently, the effectiveness of specific analgesic
strategies for treating sickle cell disease crisis related pain are mostly based on
acetaminophen and opioid derivates combination along with oxygen delivery. Those strategies
are effective but may last up to half an hour to obtain pain relief. This delay mostly
depends on the availability of venous access and on individual patient response to treatment.
Nitrous oxide is a volatile efficient analgesic therapy that has been repeatedly shown to
allow rapid analgesia in the emergency department setting.
The investigators hypothesise that a new analgesic strategy (rapid optimized analgesic
strategy) including nitrous oxide and nefopam would be as safe and more rapidly effective
than current analgesic strategy.