Effectiveness of Nebulized Dexmedetomidine for Treatment of Obstetric Post-Dural Puncture Headache
Status:
Completed
Trial end date:
2021-02-28
Target enrollment:
Participant gender:
Summary
Postdural puncture headache (PDPH) is a common complication, following neuraxial techniques.
The obstetric population is particularly prone to PDPH. Therefore, treatment of PDPH is a key
issue in obstetric anesthesia.
Dexmedetomidine is a highly selective, centrally acting α2-adrenergic agonist with analgesic
and anxiolytic effects. Moreover, it decreases cerebral blood flow (CBF) in humans and
animals secondary to cerebrovascular vasoconstriction. It has been used via the intranasal
and inhalational routes for many purposes including premedication, sedation and postoperative
analgesia. Because of its desirable properties, we hypothesized that dexmedetomidine
nebulization could be effective in the treatment of patients suffering from PDPH after
caesarean section.