Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1
Status:
Completed
Trial end date:
2004-09-01
Target enrollment:
Participant gender:
Summary
Stress is one of the more common reasons cited by addicts for continual drug use and relapse.
Treatment approaches that target both drug-induced and stress-induced relapse may prove to be
more beneficial than targeting drug-induced relapse alone. Lofexidine is a drug that reduces
the physical symptoms of opiate withdrawal and may prove to have stress-reducing capabilites
in drug addicts. The purpose of this study is to determine the maximal safe dose of
lofexidine tolerated in naltrexone-treated heroin addicts and to find an optimal lofexidine
induction schedule.