Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effects of d-amphetamine and modafinil, when given alone and in combination, in treating cocaine dependent individuals.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The University of Texas Health Science Center, Houston
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Amphetamine; Armodafinil; Cocaine; Dextroamphetamine; Modafinil

Criteria

Inclusion Criteria:

• Meets Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV (SCID) criteria for cocaine abuse or dependence

• In general good health. Individuals who are HIV-positive will not be excluded if in good general health, unless medication interactions exist.

Exclusion Criteria:

• Meets diagnostic criteria for psychiatric disorders, including other forms of drug dependence, other than nicotine

• Current cardiovascular disease, as determined by an electrocardiogram

• On probation or parole if the circumstances do not allow study completion or if ethical constraints of supervision do not allow confidentiality

• Previously received treatment with d-amphetamine, modafinil, or aripiprazole

• Currently receiving prescribed medication