Overview

Effectiveness of Low-Dose Ketamine and Intravenous Lidocaine Vs. Fentanyl for Postoperative Pain for Patients Undergoing Elective Gynecologic Surgery

Status:
COMPLETED
Trial end date:
2024-08-20
Target enrollment:
Participant gender:
Summary
Background: Rational approaches to perioperative patient management have been used to meet intraoperative analgesic needs and avoid opioid-related adverse effects, a combination of drugs, such as ketamine, sodium channel blockers, anti-inflammatories, and alpha-2 agonists can be used. This study aimed to compare the effectiveness of low-dose ketamine and intravenous lidocaine with fentanyl for intraoperative pain in patients undergoing gynecologic surgery. Objective: To determine the effectiveness of low-dose ketamine and intravenous lidocaine versus fentanyl for intraoperative pain in patients undergoing elective gynecologic surgery under general anesthesia at Dilla University General and Teaching Hospital and Hawassa University Specialized and Comprehensive Hospital from April 10, 2023, to June10, 2023. Methodology: A multicentered, randomized, controlled, single-blind trial will be conducted with 68 adult patients undergoing elective gynecologic surgery under GA. Eligible patients undergoing gynecologic surgery in both study areas will be allocated by a computer-generated random allocation sequence in equal ratios to the treatment group (T) receiving receive low dose ketamine and IV lidocaine and control group (C) receiving fentanyl. The primary outcome variable is the postoperative pain score measured at PACU, 6hour, 12 hours, and 24 hours postoperatively. Secondary outcomes are analgesic consumption, postoperative hypoxemia, Quality of immediate postoperative recovery assessed by the quality of recovery (QoR-40) questionnaire on postoperative days 1, and postoperative nausea and vomiting. Will be collected up to 24 hours postoperatively. Data will be analyzed using Student's t-test, analysis of variance, chi-square test, and Mann-Whitney test. Parametric and non-parametric categorical data will be analyzed using the chi-squared test and Fisher's exact test, respectively. Statistical significance will be a p-value of 0.05. Work plan and budgeting: - study will be conducted from April 10, 2023, to June 10, 2023, with a cost of 41625 ETB.
Phase:
PHASE4
Details
Lead Sponsor:
Dilla University