Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

• Status: Completed
• Trial end date: 2020-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: MercyOne Des Moines Medical Center
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Adults 18 years of age and older

• Presenting to the ED with a chief complaint of severe depression or suicidality, or presenting to the ED with any other chief complaint but answering "yes" to "Thoughts of harming/killing yourself?" during intake/triage

Exclusion Criteria:

• Acute mania or psychosis

• Enrollment in trial during a prior emergency department visit

• History of ketamine abuse or dependence

• Known hypersensitivity to ketamine

• Acute intoxication with any drug of abuse (including alcohol)

• Pregnancy or lactation

• Any condition that would place the patient at serious risk of harm from an increase in blood pressure (e.g. history of intracerebral hemorrhage, aneurysmal vascular disease, or arteriovenous malformation)

• Assessing provider does not want to enroll patient for any other reason, based on their clinical judgement