Effectiveness of KAE609 in Reducing Asexual & Sexual Blood-stage P.Falciparum Infection & Infectivity to Mosquitos
Status:
Terminated
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
This is a single-center open label study conducted in multiple sequential cohorts using
Induced Blood Stage Malaria infection in healthy volunteers to characterize the effectiveness
of KAE609 against sexual and asexual blood stage forms of Plasmodium falciparum. This study
is divided in 2 parts (Part A and part B). A total of 8 healthy volunteers per cohort will be
enrolled. Based on the results of Part A, Part B will be undertaken to evaluate the effect of
KAE609 following pretreatment with Piperaquine on sexual stage/gametocytemia and its activity
as an inhibitor of onward transmission to mosquito vectors using experimental mosquito
feeding assays.