Effectiveness of Intracoronary Injection of Eptifibatide in Primary Coronary Intervention in STEMI Patients
Status:
Unknown status
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
The achievement of high local concentration of Eptifibatide, a GP 2b3a inhibitor,via direct
intracoronary injection, promotes (in vitro) clot disaggregation. It remains unclear if it is
of superior benefit than the routine intravenous administration of these agents.
In patients presenting with acute myocardial infarction, and undergoing primary coronary
intervention, intracoronary administration of Eptifibatide may increase local drug
concentration by several orders of magnitude and promote clot disaggregation with a minimal
increase in systemic drug concentration, and in that way enhancing myocardial perfusion and
survival.