Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery
Status:
Not yet recruiting
Trial end date:
2023-07-31
Target enrollment:
Participant gender:
Summary
Ischemia and reperfusion injury during free flap reconstructive surgery creates a state of
increased oxidative stress that can adversely affect the flap outcomes. Ascorbic acid (AA)
had been proven to have beneficial effect on end-organ protection and flap survival from
ischemia-reperfusion injury via its antioxidant properties.
The investigators hypothesise that perioperative parenteral ascorbic acid treatment may
reduce oxidative stress among participants undergoing free flap reconstructive surgery along
with reduction in inflammatory markers, improved rate of flap viability and wound healing at
both donor and recipient sites.