Overview

Effectiveness of High-dose Zinc Therapy and Albendazole in the Treatment of Environmental Enteropathy

Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to investigate the therapeutic effectiveness of high-dose zinc therapy and de-worming albendazole as separate interventions in restoring normal gut absorptive and immunological function as measured by the dual sugar permeability test and additional biomarkers in 1-3 year old rural Malawian children at high risk for Environmental Enteropathy.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Washington University School of Medicine
Treatments:
Albendazole
Zinc
Criteria
Inclusion Criteria:

- 1-3 years of age

- Lives in study villages

Exclusion Criteria:

- Unable to drink 100 mL of sugar water

- Demonstrating evidence of severe acute malnutrition, WHZ < or = -3, presence of
bi-pedal pitting edema

- Apparent need for acute medical treatment for an illness or injury

- Parent refusal to participate and return for 7-week follow-up