Effectiveness of D-Cycloserine as an Aid to Enhance Learning for Individuals With OCD Receiving Behavior Therapy

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study will assess the effectiveness of Seromycin (D-cycloserine) in enhancing the positive effects of behavior therapy for people with Obsessive-Compulsive Disorder (OCD).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: Hartford Hospital
• Treatments: Cycloserine

Criteria

Inclusion Criteria:

• Structured Clinical Interview for DSM-IV (SCID) diagnosis of Obsessive Compulsive Disorder

• Score of greater than 16 on the Yale-Brown Obsessive Compulsive Scale

• Negative urinary beta-Human Chorionic Gonadotropin (hCG) test

Exclusion Criteria:

• Currently taking or have taken an unstable dose of psychotropic medications within 2 months prior to enrollment

• Currently taking medications that may interfere with the study medication

• History of seizure disorder or other serious medical illnesses (e.g., cardiovascular, liver, kidney, respiratory, endocrine, neurologic, or blood-related disease)

• Current diagnosis of tuberculosis

• Other psychiatric diagnoses (e.g., alcohol dependence, bipolar disorder, psychosis, organic mental disorder, or development disorder) that are of greater concern than the obsessive-compulsive disorder diagnosis

• Currently taking medications that may lower seizure threshold (e.g., including clozapine, pethidine, and the following antibiotics in high dosage: penicillins, cephalosporins, amphotericin, and imipenem)

• Poses a serious suicidal or homicidal threat

• Currently undergoing psychotherapy

• Failure to benefit from ten or more sessions of previous Exposure and Response Prevention (ERP) treatment

• Pregnant or breastfeeding