Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD
Status:
Recruiting
Trial end date:
2024-03-30
Target enrollment:
Participant gender:
Summary
Obstructive sleep apnea (OSA) is commonly reported in Veterans with post-traumatic stress
disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and
worsen nightmares. Continuous positive airway pressure (CPAP) is the most effective therapy
but adherence to treatment is suboptimal. Insomnia is considered a barrier to long-term
adherence. The overarching theme of the proposal is to compare the effectiveness of cognitive
behavioral therapy for insomnia (CBT) plus eszopiclone, a nonbenzodiazepine hypnotic, versus
CBT alone in Veterans with PTSD who are diagnosed with both OSA and insomnia, using a
randomized, clinical trial, on sleep quality of life, PTSD severity, and CPAP adherence.