Effectiveness of Bupropion for Treating Nicotine Dependence in Young People

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Little is known about the best ways to help young people stop smoking. Bupropion (a medication marketed as Wellbutrin or Zyban) has proved helpful in treating adult smokers. The purpose of this study is to determine if bupropion is also effective in treating smokers between the ages of 12 and 25 years old. This study also compares the effectiveness of bupropion used as a supplement to behavioral treatment versus behavioral treatment used alone. In addition, the study evaluates whether hormonal response to stress measured prior to the start of treatment predicts whether individuals respond well to treatment with medication.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Has smoked at least 10 cigarettes each day for 3 or more months

• Weighs at least 90 lbs

• Motivated to quit smoking and has had at least one previous failed attempt

• Speaks, reads, and writes English

• Either diagnosed as depressed OR no history of a psychiatric disorder

Exclusion Criteria:

• History of bipolar disorder, eating disorder, schizophrenia, schizoaffective disorder, autism, or non-nicotine substance use disorder in the 6 months prior to study entry

• Currently suicidal or with a history of a suicide attempt in the 6 months prior to study entry

• Psychotic symptoms

• Use of psychotropic medication(s)

• Serious medical condition

• Prior use of bupropion for smoking cessation

• Currently using other smoking cessation treatments