Effectiveness of Antibiotic Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease

• Status: Completed
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effectiveness of antibiotic therapy for patients with acute exacerbations of mild-to-moderate chronic obstructive pulmonary disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Catalan Society of Family Medicine
• Collaborator: Fondo de Investigacion Sanitaria
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

• Acute exacerbations (at least one criterion present: increase of dyspnoea, increase of sputum production and/or increase of purulence) of

• patients older than 40 years old,

• smokers or ex-smokers of more than 10 pack-years,

• with COPD and FEV1 greater than 50%, diagnosed by spirometry and a predicted ratio FEV1/FVC<0.7%.

Exclusion Criteria:

• Severe COPD (FEV1<50%)

• Pneumonia

• Active neoplasm

• Tracheotomy

• Criteria for hospitalisation

• Patients previously being on antibiotics

• Immunodepressed patients

• History of hypersensitivity to beta-lactams or intolerance to clavulanate

• Enrollment in other clinical trials

• Patients who refuse to take part in this study

• Patients who have not had a spirometry test for the past two years