Effectiveness of Adding Hyaluronidase to Bupivacaine in Ultrasound Guided Supraclavicular Brachial Plexus Block
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Background Brachial plexus block is a good choice for surgeries of the upper limb because it
provides good quality of anesthesia and analgesia especially in patients with multiple
comorbidities and in ambulatory surgery. Hyalaluronidase is a local anesthetic adjuvant used
for ophthalmologic surgery. We evaluated the effect of adding hyaluronidase to bupivacaine as
regard the onset and duration of motor and sensory block in ultrasound guided supraclavicular
brachial plexus block.
Methodology prospective, randomized and double-blind study conducted at Sohag University
Hospital. A total of 40 adults scheduled for upper limb surgery, ASA I or II were randomly
assigned into two groups (n=20). Group I received bupivacaine 0.375 % 15 mL + normal saline
4ml +hyaluronidase 800 IUin 1 ml. Group II received bupivacaine 0.375% 15 mL + normal saline5
ml. Both groups will be compared for onset and duration of sensory and motor block, duration
of analgesia and complications.
Results The onset of sensory and motor block was significantly faster in hyaluronidase group
than control group. Significant difference could not be detected in either duration of the
sensory or motor block between the two groups.
Conclusion The use of hyaluronidase as an additive to bupivacaine fastens the onset of
sensory and motor block of the brachial plexus in supraclavicular approach without affecting
the duration of the block.