Effect(s) of Esketamine Combined With Pregabalin on Postsurgical Pain in Spinal Cord Neoplasms Patients
Status:
Not yet recruiting
Trial end date:
2022-11-30
Target enrollment:
Participant gender:
Summary
Postsurgical pain is now known to be one of the most common and difficult-to-treat
complications of surgery. Persistent pain can significantly impair patients' quality of life,
social functioning and contribute to excessive health care expenditures. It is worth noting
that acute postoperative pain may play a vital role in central sensitization and
up-regulation of pain receptors, factors implicated in the development of CPSP. Poorly
perioperative pain management may increase the incidence of CPSP. According to previous
studies, the incidence of postoperative pain among patients undergoing spinal surgery was
nearly 40%. At the same time, perioperative pain management of patients undergoing spinal
surgery has not been clearly. For the past few years, pregabalin and esketamine are becoming
important roles in perioperative pain management, lots of studies have shown that these two
analgesics might relieve postoperative pain. The aim of this study was to evaluate the
analgesic effects of esketamine and pregabalin in combination after spinal cord neoplasms
resection, so as to find a better way to help the patients undergoing spinal surgery keep
away from the perioperative pain.