This trial is designed to compare the effects of twice-daily exenatide and twice-daily
placebo on weight loss. This trial will evaluate overweight and obese subjects with type 2
diabetes who have inadequate glycemic control with metformin, sulfonylurea, or metformin plus
a sulfonylurea. Subjects will be treated with exenatide or placebo in addition to their
current oral antidiabetes agent regimen and participate in a lifestyle modification program.