Effect on Post-operative Pain of Tranexamic Acid Injection During Shoulder Surgery
Status:
Not yet recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
Tranexamic acid exerts an anti-haemorrhagic activity by inhibiting the fibrinolytic
properties of plasmin. A complex involving tranexamic acid, plasminogen is constituted; the
tranexamic acid being linked to plasminogen when transformed into plasmin. The activity of
the tranexamic acid-plasmin complex on the activity on fibrin is lower than the activity of
free plasmin alone. In vitro studies showed that high tranexamic dosages decreased the
activity of complement.