Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The aim of this study is comparing the effect on cerebral oxygenation by
sevoflurane-remifentanil or propofol-remifentanil anesthesia in patient undergoing carotid
endarterectomy. Cerebral oxygenation is measured by near-infrared spectroscopy. Sevoflurane
and propofol reduce the cerebral metabolic rate for oxygen in similar degree. Propofol
decrease the cerebral blood flow by dose-dependent manner, however, sevoflurane increase the
cerebral blood flow in the concentration of avobe 1 MAC. Both drugs are widely used in
general anesthesia for neurosurgical procedure, and their effect on cerebral oxygenation are
acceptable. There is little data about the effect of general anethetics on cerebral
oxygenation in patients undergoing carotid endarterectomy, who have imparied cerebral
circulation. Our hypothesis is sevoflurane will show better cerebral oxygenation than
propofol in patient have impaired cerebral circulation.