Effect of the Use of Anticoagulant Therapy During Hospitalization and Discharge in Patients With COVID-19 Infection
Status:
Recruiting
Trial end date:
2020-12-30
Target enrollment:
Participant gender:
Summary
Viral infections provoke the systemic inflammatory response and cause an imbalance between
the procoagulant and anticoagulant homeostatic mechanisms. Multiple pathogenic mechanisms are
involved, including endothelial dysfunction, increased von Willebrand factor, Toll receptor
activation, and tissue factor pathway activation. D-dimer levels greater than 1000 ng / mL
are associated with an 18-fold increased risk of mortality. In this context, many patients
may require prophylaxis or antithrombotic treatment with low molecular weight heparins.
Currently, there is no validated scheme on the dose and timing of the use of antithrombotic
drugs.
The study aims to identify the effect of two anticoagulant strategies (prophylactic and
therapeutic) on the progression to ventilatory support or death in patients with COVID-19
infection who require hospital care.
Phase:
N/A
Details
Lead Sponsor:
Hospital Regional de Alta especialidad de Ixtapaluca