Effect of the Interferon Alpha Citizen by Sub-Lingual Way on the Humoral Immunizing Answer
Status:
Terminated
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Influenza vaccination reduces the morbidity and mortality associated with influenza infection
in at risk groups including the elderly and individuals with an impaired immune response, but
is not totally protective in all recipient. Cytokines including type I interferons are known
to play a key role in the innate immune response to virus infection and in the induction of
the primary adaptive-immune response. Thus, we evaluated the safety of sublingual
administration of IFNa and its effect on immune response to influenza vaccination in a
randomized double-blind placebo controlled study in elderly institutionalized individuals.