Effect of the Antihistamine Injection to Prevent Paradoxical Reaction During Sedative Endoscopy
Status:
Enrolling by invitation
Trial end date:
2020-04-14
Target enrollment:
Participant gender:
Summary
This single-blind prospective study is aimed to investigate the effect of antihistamine as an
adjunctive sedative for the patients with histories of severe paradoxical reaction to
midazolam during sedative endoscopy. Participating patients are to receive antihistamine
intravenously in addition to midazolam. The primary outcome is the reduction of paradoxical
reaction in the antihistamine combination group. The secondary outcome is to compare sedation
quality, performance quality, reduction of total midazolam dose will be analyzed between
antihistamine combination and midazolam only group.
Phase:
N/A
Details
Lead Sponsor:
Seoul National University Hospital
Treatments:
Chlorpheniramine Histamine Antagonists Histamine H1 Antagonists Hypnotics and Sedatives Midazolam