Overview

Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH

Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
0
Participant gender:
All
Summary
Pulmonary hypertension is characterized by an increase in the pressures in the blood supply to the lungs greater than a mean pressure of 25mmHg and a concomitant increase in overall pulmonary vascular resistance (PVR). In patients who have remodeling of their pulmonary vasculature, PVR will increase with exercise instead of decreasing as it would in normal patients. Based on published evidence, the investigators intend to investigate the effects of inhaled nitric oxide (iNO) on patients undergoing standard exercise techniques who have separately and previously had an implanted pulmonary artery monitoring device (CardioMems by St Jude Medical, Inc.) placed.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Allegheny Singer Research Institute
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Treatments:
Nitric Oxide
Criteria
Inclusion Criteria:

- Males or females age 18 to 80 years with a diagnosis of pulmonary arterial
hypertension (WHO Group I pulmonary hypertension).

- Must be able to read and understand English and consent for themselves

- Previously implanted CardioMems continuous PA pressure

- Ambulatory and able to complete 6MWD test.

Exclusion Criteria:

- Pregnant or lactating females; negative pregnancy test as confirmed by evaluation of
data from pre-enrolled Risk Evaluation and Mitigation Strategies (REMS) program.