Effect of iNO on Invasively Derived Pulmonary Pressures in Patients With PAH
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Pulmonary hypertension is characterized by an increase in the pressures in the blood supply
to the lungs greater than a mean pressure of 25mmHg and a concomitant increase in overall
pulmonary vascular resistance (PVR). In patients who have remodeling of their pulmonary
vasculature, PVR will increase with exercise instead of decreasing as it would in normal
patients. Based on published evidence, the investigators intend to investigate the effects of
inhaled nitric oxide (iNO) on patients undergoing standard exercise techniques who have
separately and previously had an implanted pulmonary artery monitoring device (CardioMems by
St Jude Medical, Inc.) placed.
Phase:
Phase 2
Details
Lead Sponsor:
Allegheny Singer Research Institute Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)