Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
The hypothesis underlying the proposed study is that the blunted endothelium-dependent
vasodilation seen in the airway of current smokers is also present in the brachial artery,
and that the same inhaled corticosteroid (ICS) treatment regime that reversed endothelial
function in the airway of current smokers will also restore endothelium-dependent relaxation
in the brachial artery. Non-smokers will be used as controls and will not receive any
intervention or treatment.