Effect of a Synbiotic on Symptoms of Patients With STC

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the efficacy of synbiotic (BIFICOPEC) containing Enterococci, Bifidobacteria, Lactobacilli triple viable bacteria and pectin in patients with slow transit constipation.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jinling Hospital, China
• Treatments: Pectin

Criteria

Inclusion Criteria:

1. age ≥ 18 years;

2. BMI: 18.5-25kg/m2;

3. chronic constipation was diagnosed according to RomeⅢ criteria;

4. colonic transit time (CTT) >48 hours;

5. mild-to-moderate constipation with wexner constipation scale between 16 and 25.

Exclusion Criteria:

1. megacolon, intestinal obstruction, inflammatory bowel disease, and cancer;

2. secondary constipation (i.e. drugs, endocrine disorders, neurological disorders, metabolic disorders, psychological disorders or abdominal surgery);

3. severe anterior rectocele or full thickness rectorectal intussusception according to defecography;

4. pregnant or lactating women;

5. infection with enteric pathogen;

6. usage of antibiotics or proton pump inhibitors (PPIs);

7. hepatic, renal, cardiovascular, respiratory or psychiatric disease;

8. other diseases or factors evaluated by the investigator which could influence intestinal transit or intestinal microbiota.