Effect of a Higher Blood-pressure on Right Ventricular Function

• Status: Completed
• Trial end date: 2020-05-25
• Target enrollment: 0
• Participant gender: All

Summary

Right ventricular (RV) dysfunction in cardiac surgery is an independent risk factor for morbidity and mortality. Raising the systemic blood pressure with norepinephrine seems to have a positive influence on the right ventricular function in several animal studies. The current study is designed to evaluate the effect of a higher blood pressure on the RV function in post cardiac surgery patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical Centre Leeuwarden
• Treatments: Norepinephrine

Criteria

Inclusion Criteria:

• post operative cardiac surgery patients, full sternotomy

• admission at ICU

• informed consent

• right ventricular monitoring by pulmonary artery catheter.

• RVEF <30% + MAP ≤ 65mmHg

Exclusion Criteria:

• no informed consent

• acute surgery

• Off pump cardiac surgery

• Severe tricuspid insufficiency

• Allergy to norepinephrine

• Severe left ventricular hypertrophy with systolic anterior movement

• Chronic use of alpha-blockers

• Irregulair heart rhythm

• Surgical reasons to maintain a low blood pressure.