Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes"
Status:
Not yet recruiting
Trial end date:
2024-04-01
Target enrollment:
Participant gender:
Summary
Between 16% and 22% of type 1 diabetic patients present a clinical and biological profile of
insulin resistance favored by a family history of type 2 diabetes or metabolic syndrome. They
constitute a group of patients with "double diabetes" since they have both true type 1
diabetes and inherited insulin resistance, typical of type 2 diabetes.
For several years, GLP1 agonists have been successfully used in the treatment of type 2
diabetes, leading to very significant improvements in glycemic control and weight loss.
Because of the insulin-sensitizing power of GLP1 agonists, the investigators hypothesize that
they could reduce insulin resistance in patients with "double diabetes" and thus improve
their glycemic control.
The investigators propose to use in this study semaglutide, the most recent and most potent
GLP1 agonist (superiority demonstrated compared to exenatide LP and dulaglutide) and
administered as a weekly subcutaneous injection (in contrast to liraglutide administered
daily).