Effect of Vitamin d Deficiency in Chronic Rhinosinusitis With Nasal Polyposis

• Status: Recruiting
• Trial end date: 2020-10-20
• Target enrollment: 0
• Participant gender: All

Summary

Aim of the work

1. To determine if chronic rhinosinusitis with nasal polyps' (CRSwNP) populations are vitamin D deficient.

2. To determine the possible anti-inflammatory effect of vitamin D supplementation (clinically & histologically). & investigate its relation to immunohistochemical tissue expression of basic fibroblast growth factor

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Vitamin D

Criteria

Inclusion Criteria:

• Patients (18-60) years of age with clinical diagnosis of chronic rhinosinusitis with nasal Polyposis (CRSwNP) at Otorhinolaryngology outpatient clinic, Ain Shams University hospital.

Exclusion Criteria:

• • Pregnant and lactating females.

• Patients taking multivitamins containing vitamin D for at least six months.

• Immune deficiency or suppression.

• Ciliary motility disorders.

• Wegner's granulomatosis and other granulomatous diseases.

• Sino-nasal malignancy.