Effect of Ursodeoxycholic Acid on Peritoneal Function in Patients on Peritoneal Dialysis
Status:
Unknown status
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal
dialysis (PD) for long period of time. Although the exact mechanisms of peritoneal damage
during PD still remain unclear, generation of Endoplasmic reticulum (ER) stress may be
responsible for progressive membrane dysfunction. Ursodeoxycholic acid (URSA) is a powerful
inhibitor of ER stress to protect peritoneal fibrosis in peritoneal dialysis in the
investigators in-vitro study. In this study the researchers investigated the hypothesis that
URSA protect peritoneal membrane damage.