Effect of Ubiquinol Supplementation on Ovulation Induction in Clomiphene Citrate Resistance
Status:
Completed
Trial end date:
2020-07-31
Target enrollment:
Participant gender:
Summary
Objective: To evaluate potential benefits of adding the active form of Coenzyme Q10
(Ubiquinol) to Clomiphene Citrate compared with Human Menopausal Gonadotropins (hMG) in
Clomiphene Citrate resistant PCOS patients.
Methods: 148 PCOS Patients with Clomiphene Citrate resistance were randomized into two groups
(A and B). In group A, controlled ovarian stimulation was done by Clomiphene Citrate 150 mg
daily (from 2nd till 6th day of cycle) together with Ubiquinol starting from 2nd day till day
of hCG triggering in a dose of 100 mg orally once daily. In group B, hMG was given from 2nd
day of the cycle in a dose ranging from 75 to 225 IU. Serial transvaginal ultrasonography was
done starting on cycle day 8 and continued till size of leading follicle reaches 18 mm or
more then ovulation triggering was done. Thereafter, patients were advised for a timed
intercourse (TI) after 36 hours. A blood sample was withdrawn seven days after hCG
triggering, for measurement of serum progesterone. If the Patient presented with a missed
period for one week, a serum sample was sent for β-hCG.