Effect of Two Toothpastes on Bacteria in Saliva

• Status: Completed
• Trial end date: 2014-11-27
• Target enrollment: 0
• Participant gender: All

Summary

This study investigated the ability of two zinc-containing toothpaste formulations (Zinc A and Zinc B) to reduce the level of bacteria in saliva in the two-hour period after their use, compared to the effect of rinsing with water alone.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Zinc

Criteria

Inclusion Criteria:

• Personnel: GSKCH permanent and contract/contingency workers.

• Consent: Demonstrated understanding of the study and was willing to participate and had received a signed and dated copy of the informed consent form.

• Compliance: Understood, was willing and able and complied with all study procedures and restrictions.

• General Health: Good general health

• Oral Health: Good oral health

• Salivary Flow Rate: Had a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2milliliter per minute (ml/min); stimulated whole saliva flow rate ≥ 0.8ml/min)

Exclusion Criteria:

• Study personnel: Members of the clinical study staff.

• Pregnancy: Pregnant Women

• Breast-feeding: Women who were breast-feeding.

• Allergy/Intolerance: Had Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.

• Medication: a) Used an antimicrobial mouthwash within 48 hours of the test visit e.g. Listerine, Corsodyl etc. b) had taken, antibiotics within 2 weeks of the test visit.

• Oral Surgery and Dental Conditions: a)Had an on-going dental treatment b) Had any oral surgery or extraction within 6 weeks of screening c) Symptoms of oral pain or any self-reported oral ulcers or herpetic lesions

• Clinical Study Participation: a) Participation in a clinical study where they received an investigational drug within 2 weeks of the screening visit b) Previously participated in this study.

• Substance Abstinence: Participant who were unwilling to abstain from smoking for at least 2 hours prior to treatment visits.