Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Main objective : Show that treatment with metformin in patients with type 2 diabetes has an effect on alternative splicing of the insulin receptor.

Secondary objective : demonstrate that the effect on the ratio A/isoform B isoform with discontinuation of treatment with metformin can be réversé by the resumption of metformin treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète; Centre d’Etudes et de Recherche pour l’Intensification du Traitement du Diabète
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Type 2 Diabetic patients usually treated with metformin (≥ 1400 mg/day), associated or not to other oral anti-diabetic treatment or. injection treatment

• Patients major.

• Patients with a social security number

• Patients having signed a consent to participate in the study

Exclusion Criteria:

• Intolerance metformin

• Patients with type 1.

• Patients on pioglitazone or rosiglitazone

• Renal failure by an anomaly of the creatinine clearance (< 60 mL/min).

• Patients pregnant or likely to be.