Effect of Tramadol Versus Morphine on PD1 and PD1-ligand in Patients With Chronic Cancer Pain

• Status: Recruiting
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

this work is looking for comparison between the effect of tramadol versus morphine on PD1 and PD1-ligand in patients with chronic cancer pain

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Morphine; Tramadol

Criteria

Inclusion Criteria:

• patients with cancer pain of varying etiology,

• documented metastatic cancer, currently on step I WHO ladder and whose pain necessitates a shift to step II,

• those who have never received radiotherapy, chemotherapy, or immunosuppressive drugs, -- and in good general and nutritional condition and without infectious diseases at the time of investigation.

Exclusion Criteria:

• abnormal hepatic, renal, and pulmonary function, gastrointestinal pathology, and

• those with cerebral metastases and/or psychological disorders,

• patients with contraindication to morphine or tramadol according to their respective data sheets, and

• patients who could not complete the diary information correctly.