Effect of Total Intravenous Anesthesia vs Inhalational Anesthesia on the Level of Inflammatory Markers
Status:
NOT_YET_RECRUITING
Trial end date:
2026-10-01
Target enrollment:
Participant gender:
Summary
This study aims to compare the effects of total intravenous anesthesia (TIVA) vs inhalational anesthesia on postoperative levels of inflammatory markers, length of hospital stay, and the incidence of postoperative nausea and vomiting in patients undergoing inguinal hernia repair.
Number participants:
Participants will be divided into 2 groups with sample size of at least 20 patients per group.
Plan of the work:
All patients will receive general anesthesia according to Ain Shams hospital protocol which follows the standards of the American Society of Anesthesiologists. Group A (TIVA group) will receive 1 g/kg IV dexmedetomidine over 10 min, 1 g/kg IV fentanyl, 2 mg/kg IV propofol, and 0.5 mg/kg IV atracurium. Maintenance of anesthesia will be achieved by 0.5 g/kg/h dexmedetomidine IV infusion and 6-12 mg/kg/h propofol IV infusion titrated according to bispectral index value (BIS) with target BIS 40-60. Group B (Sevoflurane group) will receive 1 g/kg IV fentanyl, 8% sevoflurane via face mask and 0.5 mg/kg IV atracurium. Maintenance of anesthesia will be achieved with 2%-4% sevoflurane titrated according to BIS with target BIS 40-60.
Sample Collection and Laboratory Analysis:
Venous blood samples for levels of IL-6, CRP, ferritin, and NLR will be collected from each patient at three time points:
preoperative (baseline, sample 0), 6 hours postoperative (sample 1), and 24 hours postoperative (sample 2).