Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
Status:
Completed
Trial end date:
2007-03-01
Target enrollment:
Participant gender:
Summary
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at
eradicating a potential infection. In addition, the antibiotic should have a rapid onset of
action, effectively penetrate the target tissue, and be safe and not toxic to any layer of
the healing cornea, especially the epithelium. Several studies have investigated the toxicity
of the fourth generation fluoroquinolones on the corneal epithelium and studies have
demonstrated that gatifloxacin is less deleterious to the healing cornea than moxifloxacin.
Most of these studies, however, have been conducted in animals. This was a retrospective
chart review.
Details
Lead Sponsor:
Donnenfeld, Eric, M.D.
Treatments:
Fluoroquinolones Gatifloxacin Moxifloxacin Norgestimate, ethinyl estradiol drug combination