Effect of Thymoquinone Extracted From Nigella Sativa in the Treatment of Arsenical Keratosis

• Status: Recruiting
• Trial end date: 2021-02-20
• Target enrollment: 0
• Participant gender: All

Summary

Prepare an ointment from Nigella sativa seeds extract and apply it over palmer arsenical keratosis patient for 12 weeks. After than the effect of the ointment will be observed by measuring the keratotic nodular size before and after the intervention.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Criteria

Inclusion Criteria:

• Age: 19 - 65 years

• Arsenical keratosis: Presence of moderate to severe keratosis (>5 mm) in both palms or soles

• Drinking arsenic-contaminated water (>50 µg/ L) for at least more than six months

• Patient did not receive topical application of any drug for the last three months

• Patient agreed to participate voluntarily

• Patient who understood the instruction of applying drug and could apply drug as per an instruction

Exclusion Criteria:

• Age <19 and >65 years

• Pregnant and nursing mother

• Patient who received any treatment of arsenicosis within the last three months

• Patient with skin diseases like atopic dermatitis, eczema, and psoriasis

• Any systemic disease, inflammatory disease and infectious condition that affected the skin, for example, diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus and hepatitis

• Food allergy to Nigella sativa