Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery

• Status: Not yet recruiting
• Trial end date: 2022-11-20
• Target enrollment: 0
• Participant gender: Female

Summary

This study compared the effects of prophylactic infusion of metaraminol, phenylephrine and norepinephrine adjusted according to body weight on fetal acid-base balance and maternal hemodynamics.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Xuzhou Medical University
• Treatments: Metaraminol; Norepinephrine; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

1. Singleton pregnancy at term scheduled to be delivered via elective cesarean delivery;

2. height 150-180 cm;

3. American Society of Anesthesiologists (ASA) physical status II-III;

4. body mass index (BMI) <35 kg/m2.

Exclusion Criteria:

1. transverse presentation, fetal macrosomia;

2. uterine abnormalities (eg, large fibroids, bicornuate uterus);

3. polyhydramnios;

4. ruptured membranes, oligohydramnios;

5. intrauterine growth restriction;

6. gestational or nongestational hypertension, diabetes, or eclampsia;

7. hypertensive disorders or any condition associated with autonomic neuropathy (such as diabetes mellitus for >10 years) or renal failure;

8. contraindications for combined spinal-epidural anesthesia;

9. participants who declined to sign informed consent forms.