Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

• Status: Completed
• Trial end date: 2009-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine in current and non-smokers the clinical and microbiological effects of 3 therapies: scaling and root planing (SRP) alone; SRP in combination with the orally administered antibiotic metronidazole; and SRP with the orally administered antibiotics metronidazole and amoxicillin along with the locally delivered antibiotic doxycycline at periodontal pockets >= 4 mm.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Forsyth Institute
• Collaborator: National Institute of Dental and Craniofacial Research (NIDCR)
• Treatments: Amoxicillin; Doxycycline; Metronidazole

Criteria

Inclusion Criteria:

• > 20 teeth

• > 5% sites (approx. 8 sites) with pocket depth > 4 mm and / or 5% sites with attachment level > 4 mm and mean AL < 4.5 mm and mean PD < 3.9 mm (not including tooth brush abrasions).

Exclusion Criteria:

• > 50% of sites with pocket depth or attachment level > 4 mm

• Pregnancy or nursing

• Periodontal or antibiotic therapy in the previous 6 months

• Any systemic condition which might influence the course of periodontal disease or treatment (e.g. diabetes, AIDS)

• Any systemic condition which requires antibiotic coverage for routine periodontal procedures (e.g. heart conditions, joint replacements etc.)

• Liver disease

• Any known allergy to amoxicillin, metronidazole or doxycycline

• Lactose intolerance