Effect of Theophylline in Pseudohypoparathyroidism

• Status: Not yet recruiting
• Trial end date: 2032-04-10
• Target enrollment: 0
• Participant gender: All

Summary

The study evaluates the effect of theophylline in 40 subjects with Pseudohypoparathyroidism.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Theophylline

Criteria

Inclusion Criteria:

• Subjects with known diagnosis of PHP1A and PHP1B

• Age >5 years

Exclusion Criteria:

• • Significant kidney disease, i.e. any CKD stage

• Hypercalciuria

• Kidney stones

• Severe Heart disease

• Uncontrolled seizure disorder

• Peptic ulcer

• Liver dysfunction

• Bleeding disorder

• Allergy to theophylline preparation

• Muscle disorder

• Infection

• Any neurologic disease

• Chronic drugs interacting with theophylline