Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The investigators propose a randomized, double blind, placebo-controlled, cross-over trial to
evaluate the effect of oral and topical (vaginal gel) tenofovir on genital herpes simplex
virus (HSV) shedding among herpes simplex virus type-2 (HSV-2) seropositive, human
immunodeficiency virus (HIV) seronegative women. The investigators hypothesize that tenofovir
will reduce genital HSV shedding compared to placebo.