Effect of Taurine on Portal Hemodynamics in Patients With Advanced Liver Cirrhosis

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators want to analyze the effect of Taurin on portal hemodynamics in patients with advanced liver cirrhosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Vienna

Criteria

Inclusion Criteria:

• Patients (male and female) aged older than 18 years with advanced liver cirrhosis (Child's Grade B and Child's Grade C), regardless of the disease origin (viral, alcoholic, idiopathic), who are scheduled for hepatic hemodynamic investigation

• Negative pregnancy test of women with childbearing potential

• Patient without beta blocker therapy: due to: intolerance of the medication, preexisting contraindication against beta blocker therapy, endoscopic band ligation as prophylaxis

Exclusion Criteria:

• History of variceal bleeding without endoscopic band ligation

• History of endoscopically diagnosed large varices with red spots without previous bleeding and without endoscopic band ligation

• HVPG < 10 mmHg

• HVPG > 20 mmHg and varices, unless ligated and treated in an eradication program within 6 months

• Beta Blocker therapy

• History of hypersensitivity to the trial drugs and contrast agent or to drugs with similar chemical structure

• Treatment with vasoactive or non-steroidal anti-inflammatory drugs or systematic antibiotics one week before the study

• Exclusion criteria for hepatic hemodynamic investigation

• Cardiac, renal or respiratory failure

• Previous surgical or transjugular intrahepatic portosystemic shunt

• Breast-feeding or pregnant women