Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serum Biomarkers and on PBMCs in Breast Cancer Surgery
Status:
Unknown status
Trial end date:
2018-02-01
Target enrollment:
Participant gender:
Summary
Surgery, perioperative stress, anaesthetics and analgesics may modulate the
immunosurveillance mechanisms and overwhelm host defences that normally maintain a balance
between immunity & carcinogenesis. This may lead to escape of cancer cells and tilt the
scales toward a more protumorigenic microenvironment. Volatile agents, in particular, have
been shown to exhibit profound immunosuppressive effects. In comparison, propofol has a
favorable profile and inhibits cancer cell activity. Determining "cancer-protective" role of
TIVA with propofol presents an exciting window of opportunity that has potential to improve
outcomes in cancer patients undergoing resection surgery