Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Pediatric Emergence Delirium in Sevoflurane-rocuronium Anesthesia
Status:
Completed
Trial end date:
2019-12-30
Target enrollment:
Participant gender:
Summary
The aim of this study is to investigate the effect of sugammadex vs. a conventional
acetylcholinesterase inhibitor, neostigmine on emergence delirium (ED) during
sevoflurane-rocuronium anesthesia in pediatric patients Additionally, the efficacy features
of sugammadex compared to neostigmine will be examined by measuring the time from start of
administration of reversal agents to recovery of train-of-four (TOF) ratio to 0.7, 0.8, and
0.9.
Although the etiology of ED remains unclear, a sense of suffocation or breathing difficulty
during emergence from anesthesia has been suggested as a possible cause. Thus, reversal of
neuromuscular blockade with sugammadex in pediatric patients maintained with
sevoflurane-rocuronium anesthesia may decrease ED due to its faster reversal of neuromuscular
blockade and decreased possibility of residual blockade.