Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery
Status:
Completed
Trial end date:
2014-01-01
Target enrollment:
Participant gender:
Summary
Studies have shown that surgery causes some reactions in your body consistent with
inflammation. When the inflammation is extensive, it may affect different parts of the body
including the lungs. Corticosteroids are commonly used to treat inflammation and are
different from performance enhancing steroids associated with athletics. The purpose of this
study is to determine the influence of low dose steroids given 3 times in a 24 hour period on
thrombotic markers (markers that are associated with increased risks of clotting, a possible
complication of surgery), interleukin (IL)-6 cytokine release (part of the stress response
seen with surgery), and urine desmosine levels (a marker of lung injury) in a randomized
placebo controlled trial patients undergoing total hip replacement.