Effect of Steroid Injections in a Knee With Osteoarthritis
Status:
Completed
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
A steroid (triamcinolone) 40 mg will be compared to placebo in a randomized
placebo-controlled clinical trial testing the effect of this steroid versus placebo given
into the study knee joint that has osteoarthritis (OA). The knee injection will be given once
every 12 weeks over two years for a total of eight knee injections. How well each participant
tolerates each injection and all the injections over time will be assessed. The safety of
getting a knee injection every 12 weeks will be assessed by collecting reported adverse
effects, knee examinations, and clinical laboratory tests. Participants will complete
questionnaires, X-ray, MRIs, and bone density tests as part of this study.